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Types of Common Hormone Replacement Therapy Drugs:

Prempro- Wyeth Pharmaceutical’s Prempro is the number one selling hormone replacement drug that was the source of concern and the reason why the WHI study was halted. The combination of estrogen and progestin was intended to help a woman with menopausal symptoms like hot flashes and mood swings. Prempro and Wyeth’s related product Premphase generated more than $2 billion in sales in 2001.

Premarin- Wyeth’s Premarin is an estrogen replacement therapy pill that has been available for sixty years. Estrogen replacement therapy is usually prescribed for women who have had a hysterectomy. The WHI study is still continuing on estrogen only hormone replacement therapy because researchers have not yet determined the risk and benefit of the pills. Last year, Premarin had $1.3 billion in sales.

Premphase- Premphase is a hormone replacement drug similar to the other drug Prempro, combining estrogen and progestin. As with Prempro, Premphase is for women who have not had hysterectomies.

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HRT Alternatives

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HRT (Hormone Replacement Therapy) Alternatives

The announcement of the WHI hormone replacement side effects that were found to occur in healthy women left doctors and the six million American women that were using the estrogen/progestin combination unequipped for what the future of menopausal treatment will be. For some women, discontinuing hormone replacement therapy, or HRT, will be no problem, but for the women who have been taking estrogen/progestin for many years now, it has become a way of life for them. Doctors and medical groups were not prepared for the number of questions and concerned patients after news of the unanticipated event. Doctors were forced to take their phones off the hook because they did not yet have the answers for what their patients should do.

HRT had become such a common prescription that every year 70 million prescriptions were written for HRT that doctors encouraged almost every woman that had not had a hysterectomy to use when beginning menopause. The American College of Obstetricians has just issued guidelines on the most popular HRT alternative to treat menopause. If you are currently taking hormone replacement therapy, the combination of estrogen and progestin, you are advised to contact your doctor immediately and to find a HRT alternative treatment.

If you would like to receive more information on hormone replacement therapy and HRT alternatives, contact us.

Soy and Isoflavones (plant estrogens found in beans, particularly soybeans) - Having a high isoflavone intake (about 50 grams of soy protein per day) as a HRT alternatice may be helpful in the short term (2 years or less) in relieving hot flashes and night sweats. Taken over the long term, it also may have beneficial effects on cholesterol and bones. While safe in dietary amounts, the consumption of extraordinary amounts of soy and isoflavone supplements may interact with estrogen and may be harmful to women with a history of estrogen-dependent breast cancer and possibly to other women as well.

St. John's Wort - Used as a HRT alternative, it may be helpful in the short-term (2 years or less) to treat mild to moderate depression in women (when given in doses of less than 1.2 milligrams a day.) A recent study showed it is not effective in treating severe depression. It also can increase skin sensitivity to the sun and may interfere with prescription antidepressants.

Black Cohosh - May be helpful in the short term (6 months or less) as an HRT alternative to treat hot flashes and night sweats. It seems to be extremely safe, although studies have been small and brief, none longer than six months.

Chasteberry (also known as monk's pepper, Indian spice, sage tree hemp, and tree wild pepper) - As a HRT alternative, this may inhibit prolactin, a natural hormone that acts on the breast. It is touted for breast pain and premenstrual syndrome. There are very few studies in menopausal women. A study of women with premenstrual syndrome found they reported improvements in mood, anger, headache, breast fullness, but not bloating and other symptoms.

Evening Primrose - This plant as a HRT alternative produces seeds rich in gamma-linolenic acid, which some experts believe is the nutritionally perfect fatty acid for humans. Although evening primrose capsules are taken for breast pain, bladder symptoms and menopausal symptoms, there is little or no evidence that they work. The one high quality study of effects on hot flashes found that evening primrose was no better than placebo.

Dong Quai - A study aimed at reducing hot flashes found that dong quai as a HRT alternative was not better than placebo - although the 4.5-gram dose used in the study was lower than that typically given in Chinese medicine. The herb is potentially toxic. It contains compounds that can thin the blood, causing excessive bleeding, and make the skin more sensitive to sun, possibly increasing skin cancer risk.

If you would like to receive more information on hormone replacement therapy and HRT alternatives, contact us.

Valerian Root - This has traditionally been used as a tranquilizer and sleeping aid. But the U.S. Pharmacopoeia, which sets manufacturing standards for medicines, does not support its use, and there have been reports of heart problems and delirium attributed to sudden withdrawal from valerian when used as a HRT alternative.

Ginseng - Most of the many types of ginseng (including Siberian, Korean, and American, white and red) are promoted for relieving stress and boosting immunity. A study of menopausal women by the leading ginseng manufacturer found that as a HRT alternative, the product did not relieve hot flashes but did improve women's sense of well-being. Analyses of ginseng products have found a troubling lack of quality control: some contained little or no ginseng, contained large amounts of caffeine, or was tainted by pesticides or lead.

Wild and Mexican Yam - There are no published reports that show wild and Mexican yam cream is effective in helping menopausal symptoms. The hormones in wild and Mexican yam do not have any estrogenic or progestational properties, so they are not expected to help women with these symptoms or be used as a HRT alternative.

If you would like to receive more information on hormone replacement therapy and HRT alternatives, contact us.


HRT Resources Provided below are some helpful links for more information:

The American College of Obstetricians and Gynecologists exists to serve as a strong advocate for quality health care for women, maintain the highest standards of clinical practice and continuing education for its members, promoting patient education and stimulating patient understanding of and involvement in medical care, and increasing awareness among its members and the public of the changing issues facing women’s health care. http://www.acog.org/

The North American Menopause Society is the leading scientific nonprofit organization that is devoted to promoting women’s health during midlife and beyond through an understanding of menopause. The site contains information on perimenopause, early menopause, menopause symptoms and long-term health effects of estrogen loss, and a wide variety of therapies to enhance health.

National Institute on Aging is one of the 25 institutes and centers of the National Institute of Health that leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. In 1974, Congress granted authority to form the National Institute on Aging to provide leadership in aging research, training, health information dissemination, and other programs relevant to aging and older people.

Women’s Health Initiative conducted the major clinical trial of the risks and benefits of hormone replacement therapy- the estrogen-progestin hormone combination. The trial was stopped after five years because of the serious risks found to occur in women taking the drugs. The study results revealed the benefits of the drug were far outweighed by the serious risks. For the hormone replacement therapy study information visit the Women’s Health Initiative.

National Center for Complementary and Alternative Medicine is a site that provides patients with alternatives to regular prescription medications.

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